November 1, 1972Experimental Biology and Medicine

Electrophysiologic Effects of Regional Hyperkalemia in the Canine Heart

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Population

anesthetized dogs

Design

Preclinical

Authors

JLJ. R. LogicUniversity of Tennessee at Knoxville

Discussion

Member takes

Implication

Does not support clinical changes; hypothesis-generating for hyperkalemia's role in human ischemic arrhythmogenesis.

Structured PICO

Population

anesthetized dogs

Intervention

KCl (40 mEq/liter) infused into the anterior descending branch of the left coronary artery

Outcome

electrophysiologic changes including systolic and diastolic injury currents, Q-T interval, absolute and functional refractory periods, and DTsurrogate

Regional hyperkalemia in the canine heart mimics the electrophysiologic characteristics of acute myocardial ischemia, suggesting extracellular potassium release contributes to arrhythmogenesis during myocardial infarction.

Cite This Study

J. R. Logic (1972) studied this question.

synapsesocial.com/papers/6a953d64dc88abd75325e5d6 https://doi.org/10.3181/00379727-141-36860

View Full Paper

Ask AI

Bookmark

Electrophysiologic Effects of Regional Hyperkalemia in the Canine Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiologic Effects of Regional Hyperkalemia in the Canine Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider