Key result
Ischemic acidosis worsens hyperkalemia-induced conduction slowing, increasing conduction time by ~50%.
Why the study?
Does the combination of acidosis and hyperkalemia increase conduction slowing and alter the effective refractory period in an in-situ canine heart model?
Population
20 mongrel dogs of either sex, weighing 11-27 kg, in an in-situ canine heart model.
Comparison
Regional hyperkalemia combined with either… vs Baseline/control state and individual conditions.
Design
Preclinical
Authors
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May contribute to ischemic arrhythmogenesis; leaves open translation to human conduction and ERP changes.
Does the combination of acidosis and hyperkalemia increase conduction slowing and alter the effective refractory period in an in-situ canine heart model?
Absolute Event Rate: 23.3% vs 19.1%
p-value: p=0.0051
In an in-situ canine model, the combination of acidosis and hyperkalemia synergistically exacerbates intramyocardial conduction slowing during acute myocardial ischemia.
Watanabe et al. (2018) studied Acute myocardial ischemia (n=20). Regional hyperkalemia plus acidosis (metabolic or respiratory) vs. Regional hyperkalemia alone was evaluated on Intramyocardial conduction time (CT) under respiratory acidosis plus hyperkalemia (p=0.0051). The fall in extracellular pH resulting from myocardial ischemia enhanced the conduction slowing induced by the rise in extracellular potassium, increasing conduction time by 50% compared to baseline.
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