Population
in vitro preparations from canine ventricles
Design
Preclinical
Authors
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May alter excitation pathways in ischemia; hypothesis-generating in animal models and requires human validation.
Hypoxia, hyperkalemia, and acidosis significantly increase Purkinje-ventricular junctional conduction delay, which may alter excitation pathways during myocardial ischemia.
Veenstra et al. (1987) studied this question.
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