Why the study?
Does hypercapnic acidemia preferentially depress transverse conduction velocity in the canine ventricle compared to metabolic acidemia?
Population
Anesthetized dogs
Comparison
Hypercapnic acidemia produced by increasing the… vs Acidemia produced by HCl infusion
Design
Preclinical
Authors
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Hypercapnic acidemia may promote anisotropic slowing in vivo; leaves open translation to human arrhythmia mechanisms or management.
Does hypercapnic acidemia preferentially depress transverse conduction velocity in the canine ventricle compared to metabolic acidemia?
Hypercapnic acidemia preferentially depresses transverse conduction in the intact canine heart, consistent with in vitro uncoupling of cell-to-cell communication.
Vorperian et al. (1994) studied this question.
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