Why the study?
Does procaine amide, insulin, or glucose solution alter myocardial K+ movement and ventricular arrhythmias during ischemia in dogs?
Population
Intact anesthetized dogs with an electrode catheter in the left anterior descending coronary artery for…
Comparison
Systemic procaine amide, intracoronary insulin… vs Dogs with moderate flow reduction or marked flow…
Design
Preclinical
Authors
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Hypothesis-generating for K+-targeted antiarrhythmics in ischemia; leaves open translation beyond canine models.
Does procaine amide, insulin, or glucose solution alter myocardial K+ movement and ventricular arrhythmias during ischemia in dogs?
In a canine model of myocardial ischemia, egress of K+ precedes ventricular arrhythmias, and interventions that prevent K+ loss (procaine amide, hyperglycemia) can correct or prevent the arrhythmia.
Regan et al. (1967) studied this question.
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