Key result
Higher urinary BPA levels are linked to obstructive coronary disease and higher SYNTAX scores.
Why the study?
Additional factors beyond standard modifiable cardiovascular risk factors may contribute to coronary artery disease development, including exposure to bisphenol A, an endocrine-disrupting chemical associated with cardiovascular alterations.
Cross-Sectional (n=89)
Higher urinary Bisphenol A levels correlate with increased severity of coronary artery disease and elevated biomarkers of vascular injury in Mexican adults.
Answers are grounded in this paper and cite their sources.
Elevated urinary bisphenol A may mark vascular injury risk in CAD; leaves open causality and requires prospective confirmation before clinical action.
Coronary artery disease (CAD) is a leading cause of death worldwide and is associated with standard modifiable cardiovascular risk factors (SMuRFs); however, additional factors may contribute to its development. Bisphenol A (BPA), an endocrine-disrupting chemical has been associated with cardiovascular alterations. We investigated BPA’s possible association with classic risk factors and vascular injury biomarkers in Mexican patients with CAD. Adult patients underwent quantitative coronary angiography and SYNTAX score assessment and were classified as having obstructive (OD) or non-obstructive (NOD) disease. SMuRFs, lipid profile, VCAM-1, MMP-2, MMP-9, and uBPA were determined. Data were analyzed using correlation analysis, Welch’s t-test, ANOVA, and adjusted multiple linear regression. Eighty-nine patients aged 30–85 years were evaluated. OD patients had higher uBPA levels (3.46 ± 2.04 ng/mL) than NOD patients (1.25 ± 1.08 ng/mL), and uBPA levels differed according to the number of diseased arteries and diseased artery segments. uBPA was positively associated with MMP-2, MMP-9, SYNTAX score, percentage of stenosis, number of diseased arteries, diseased artery segments, and SMuRFs, and negatively associated with HDLc. SYNTAX score was associated with MMP-2, MMP-9, VCAM-1 and low HDLc levels. Our findings support uBPA levels are associated with vascular injury in Mexican patients with coronary artery disease.
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Guerrero-Meza et al. (2026) conducted a cross-sectional in Coronary Artery Disease (n=89). Urinary Bisphenol A (uBPA) was evaluated on Vascular injury (obstructive coronary artery disease, SYNTAX score, and stenosis). Urinary Bisphenol A (uBPA) levels were higher in patients with obstructive coronary disease (3.46 ng/mL) versus non-obstructive disease (1.25 ng/mL) and positively correlated with SYNTAX score.
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