Key result
Balloon angioplasty for branch pulmonary artery stenoses yielded an overall success rate of 58%, with mean lesion diameter increasing from 3.8 mm to 5.5 mm (p=0.001).
Why the study?
The effectiveness and safety of balloon angioplasty for branch pulmonary artery stenoses across various patient groups required evaluation.
Does balloon angioplasty improve vessel diameter and hemodynamics in patients with branch pulmonary artery stenoses?
Observational (n=135)
Does balloon angioplasty improve vessel diameter and hemodynamics in patients with branch pulmonary artery stenoses?
Balloon angioplasty for branch pulmonary artery stenoses has a moderate success rate of 58%, though restenosis and serious early complications such as pulmonary artery rupture can occur.
Two hundred eighteen balloon angioplasty procedures were performed in 135 patients with branch pulmonary artery stenoses from June 1984 to February 1989. Arteries were dilated in patients with tetralogy of Fallot (n = 49), tetralogy of Fallot/pulmonary atresia (n = 64), isolated peripheral pulmonary artery stenoses (n = 58) and "other" lesions (the majority had truncus arteriosus or single ventricle and surgically induced pulmonary artery stenoses (n = 47). Mean age at dilation was 6.6 +/- 6.3 years (range 1 month to 38.5 years). The mean diameter of the lesion increased from 3.8 +/- 1.7 to 5.5 +/- 2.1 mm with dilation (p = 0.001). The overall success rate was 58% (127 of 218 dilations), assessed by the following criteria: an increase greater than or equal to 50% of predilation diameter, an increase greater than 20% in flow to the affected lung or a decrease greater than 20% in systolic right ventricular to aortic pressure ratio. Success did not correlate with patient age. Mean balloon to artery ratio was higher in successful (4.2) than in failed (3.0) angioplasty procedures (p = 0.0001). There were four early deaths: two of the patients had pulmonary artery rupture with angioplasty performed less than 1 month after pulmonary artery surgery. An aneurysm occurred in 11 arteries and transient pulmonary edema in four patients. At angiography performed a mean of 10 months (range 1 to 54) after dilation, the mean diameter of 57 arteries was unchanged (5.5 versus 5.4 mm). However, 5 of 32 initially successfully dilated vessels had returned to predilation size as a result of restenosis.(ABSTRACT TRUNCATED AT 250 WORDS)
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Rothman et al. (1990) conducted an observational in Branch pulmonary artery stenoses (n=135). Balloon angioplasty was evaluated on Overall success rate (≥50% increase in diameter, >20% increase in lung flow, or >20% decrease in RV/aortic pressure ratio). Balloon angioplasty for branch pulmonary artery stenoses yielded an overall success rate of 58%, with mean lesion diameter increasing from 3.8 mm to 5.5 mm (p=0.001).
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