Key result
Full poliovirus vaccination linked to ~53% lower poliovirus type 1 isolation.
Cross-Sectional (n=146)
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Wild poliovirus in vaccinated Nigerian children signals transmission risk; leaves open questions on OPV performance and surveillance needs.
Faecal samples collected from 114 fully vaccinated pre-school children and 32 unvaccinated infants in Ibadan, Nigeria, were assayed for poliovirus in Hep-2 and RD cell cultures. 8 strains of poliovirus type 1 were isolated from 146 samples--3 from 32 unvaccinated children aged less than 40 d and 5 from 114 fully vaccinated children aged between 9 and 60 months. Studies using Sabin and wild monoclonal antibodies and the polymerase chain reaction confirmed 7 of the 8 isolates to be of the wild type, a possible source of infection among vaccinated children.
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Adu et al. (1996) conducted a cross-sectional in Poliovirus circulation (n=146). Full poliovirus vaccination vs. Unvaccinated status was evaluated on Isolation of poliovirus type 1 from faecal samples. Full poliovirus vaccination status showed poliovirus type 1 isolation in 4.4% (5/114) of children versus 9.4% (3/32) in unvaccinated infants, with 7 of 8 total isolates being wild-type.
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