Key result
CAD is linked to higher baseline coronary sinus platelet aggregability that decreases during pacing-induced ischemia.
Why the study?
The effect of coronary artery disease and myocardial ischaemia on transmyocardial platelet aggregability was evaluated.
Observational (n=31)
Suggests trans-stenotic platelet activation in CAD; leaves open pacing effects and clinical relevance pending larger studies.
Twenty-five patients with coronary artery disease and six ‘normal’ subjects were studied during routine catheter investigation for chest pain. In vitro platelet aggregation responses were measured in arterial and coronary sinus blood samples taken at rest and after pacing. Platelet aggregability was found to be increased in coronary sinus blood from patients with coronary artery disease at rest, but it was reduced with pacing. We conclude that platelets are affected by passage through a stenosed coronary artery and that acute myocardial ischaemia exerts an anti-aggregatory effect.
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Dalal et al. (1982) conducted an observational in Coronary artery disease and myocardial ischaemia (n=31). Coronary artery disease and pacing-induced myocardial ischaemia vs. Normal subjects and resting state was evaluated on In vitro transmyocardial platelet aggregation responses in arterial and coronary sinus blood. Coronary artery disease (n=25 vs 6 controls) was associated with increased resting coronary sinus platelet aggregability that decreased after pacing-induced myocardial ischaemia.
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