January 1, 1983Thrombosis and Haemostasis
Intracoronary Platelet Release in Patients with and without Coronary Artery Disease
Key result
Although aortic plasma BTG levels were higher in CAD patients than controls (60.4 vs 47.5 ng/ml, p<0.05), no significant transmyocardial gradient of BTG was observed at rest or during pacing.
Why the study?
Does intracoronary platelet release of beta-thromboglobulin occur at rest or during atrial pacing in patients with stable coronary artery disease compared to controls?
Population
18 patients with a history of chest pain, including 11 with coronary artery disease and 7 with normal…
Comparison
Atrial pacing and rest conditions with analysis… vs Patients with normal coronary arteriograms…
Design
Case-control
Authors
Discussion
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Implication
No intracoronary BTG release detected in stable CAD; leaves open platelet activation's role in acute or exertional ischemia.
Study Design
Type
Case-Control (n=18)
Structured PICO
Does intracoronary platelet release of beta-thromboglobulin occur at rest or during atrial pacing in patients with stable coronary artery disease compared to controls?
P
Population
18 patients with a history of chest pain, including 11 with coronary artery disease and 7 with normal coronary arteriograms serving as controls.
E
Exposure
Atrial pacing and rest conditions with analysis of aortic and coronary sinus blood samples.
C
Comparator
Patients with normal coronary arteriograms (n=7) serving as controls.
O
Outcome
Intracoronary platelet release of beta-thromboglobulin (BTG) measured by transmyocardial gradient of platelet and plasma BTG content.surrogate
Main Result
Absolute Event Rate: 60.4% vs 47.5%
p-value: p=<0.05
Intracoronary platelet release does not appear to occur at rest or during atrial pacing in stable coronary artery disease, suggesting it does not contribute to exercise-induced myocardial ischemia.
Cite This Study
Verheugt et al. (1983) conducted a case-control in Coronary artery disease (n=18). Coronary artery disease vs. Normal coronary arteriograms was evaluated on Aortic plasma beta-thromboglobulin (BTG) levels (p=<0.05). Although aortic plasma BTG levels were higher in CAD patients than controls (60.4 vs 47.5 ng/ml, p<0.05), no significant transmyocardial gradient of BTG was observed at rest or during pacing.