Key result
Exercise-induced ischaemia is linked to elevated BTG and FPA in PAD but not stable angina.
Why the study?
The relationship between exercise-induced myocardial ischaemia and platelet activation and fibrin formation in patients with stable angina and severe coronary artery disease was unclear.
Does exercise-induced myocardial ischaemia cause enhanced platelet activation and fibrin formation in patients with stable angina and severe coronary artery disease?
Population
20 patients with stable angina pectoris, 10 patients with peripheral artery disease without angina, and 10 normal volunteers
Comparison
Before and after exercise-induced myocardial ischaemia in stable angina patients versus controls
Design
Observational study measuring BTG and FPA levels
Authors
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No rise in peripheral BTG/FPA after exercise ischemia in isolated stable angina; leaves open whether markers detect coronary-specific activation or comorbid atherosclerosis.
Observational (n=40)
Does exercise-induced myocardial ischaemia cause enhanced platelet activation and fibrin formation in patients with stable angina and severe coronary artery disease?
p-value: p=<0.001
Exercise-induced myocardial ischemia does not cause enhanced platelet activation and fibrin formation in isolated stable angina, and elevations seen in some patients are likely driven by concomitant peripheral artery disease.
Gallino et al. (1987) conducted an observational in Stable angina and severe coronary artery disease (n=40). Exercise-induced myocardial ischaemia vs. Rest (before exercise) and normal controls was evaluated on Betathromboglobulin (BTG) and fibrinopeptide A (FPA) levels in peripheral venous blood (p=<0.001). Exercise-induced myocardial ischaemia did not elevate betathromboglobulin or fibrinopeptide A in isolated stable angina, but increased both in those with peripheral artery disease (P<0.001, P<0.01).
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