August 1, 1988European Heart Journal
Platelet activation in angina at rest. Evidence by paired measurement of plasma beta-thromboglobulin and platelet factor 4*
Population
69 patients with proven ischaemic heart disease and 60 control volunteers. Patients were stratified by…
Design
Cross-sectional
Authors
Discussion
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Implication
May link platelet activation to ischaemic frequency in rest angina; hypothesis-generating and requires prospective trials before clinical consideration.
Structured PICO
P
Population
69 patients with proven ischaemic heart disease (IHD) and 60 control volunteers. Patients were stratified by disease activity based on the number of spontaneous ischaemic episodes at rest during 4 days of continuous electrocardiographic monitoring.
C
Comparator
60 control volunteers and internal comparison between IHD patient subgroups based on disease activity (Group I: no episodes, Group II: <1 episode/day, Group III: >1 episode/day)
O
Outcome
Plasma levels of beta-thromboglobulin and platelet factor 4surrogate
Platelet activation markers (beta-thromboglobulin and platelet factor 4) are elevated in patients with active spontaneous angina at rest, correlating with the frequency of ischaemic episodes.
Cite This Study
Caterina et al. (1988) studied this question.