Why the study?
Are platelet factor 4 (PF4) and β-thromboglobulin (β-TG) levels elevated in patients with ischemic heart disease compared to normal controls?
Population
Patients with ischemic heart disease (acute myocardial infarction and angina pectoris) and normal controls
Comparison
Measurement of platelet factor 4 and… vs Normal controls
Design
Cohort
Follow-up
10 days
Authors
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Supports platelet activation in acute MI; leaves open biomarker validation in prospective cohorts.
Are platelet factor 4 (PF4) and β-thromboglobulin (β-TG) levels elevated in patients with ischemic heart disease compared to normal controls?
PF4 and β-TG are elevated in acute myocardial infarction but not angina pectoris, serving as useful biomarkers for in vivo platelet activation.
Kim et al. (1986) studied this question.
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