Why the study?
Are plasma concentrations of platelet factor 4 increased in patients with coronary artery disease compared to angiographically normal patients?
Population
162 patients with documented coronary artery disease and a control group of angiographically normal patients
Comparison
Coronary artery disease; subgroups received… vs Angiographically normal patients
Design
Cohort
Follow-up
1 year (for CABG subgroup)
Authors
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Elevated PF4 may mark platelet activation in CAD; hypothesis-generating for biomarker utility and therapy response.
Are plasma concentrations of platelet factor 4 increased in patients with coronary artery disease compared to angiographically normal patients?
Plasma PF4 is elevated in patients with coronary artery disease, reflecting in vivo platelet activation, and is reduced by medical therapy (propranolol and nitrates) but not by CABG.
Levine et al. (1981) studied this question.
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