Why the study?
Does beta-blocker therapy modify exercise-induced platelet factor 4 release in patients with coronary artery disease?
Population
84 patients with coronary artery disease undergoing standardized treadmill exercise, and 10 healthy…
Comparison
Standardized treadmill exercise; subgroup… vs Healthy volunteers; patients not treated with…
Design
Cross-sectional
Authors
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Beta-blocker use was associated with blunted exercise-induced PF4 release in CAD; hypothesis-generating for antiplatelet effects and outcomes trials.
Does beta-blocker therapy modify exercise-induced platelet factor 4 release in patients with coronary artery disease?
Beta-blockade modifies exercise-induced platelet activation in patients with coronary artery disease, suggesting an antiplatelet effect of these agents.
Levine et al. (1984) studied this question.
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