Fibrinopeptide A is released into the coronary circulation after coronary spasm.
Why the study?
Does acute myocardial ischemia induced by coronary spasm or rapid atrial pacing activate the coagulation system and platelet activation in the coronary circulation?
Population
45 patients: 15 with coronary spastic angina, 15 with stable exertional angina, and 15 controls with chest…
Comparison
Intracoronary injection of acetylcholine to… vs Intracoronary injection of acetylcholine in…
Design
Other
Authors
Discussion
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Member takes
Implication
May link spasm to local thrombin generation; hypothesis-generating in small observational data and leaves open any therapeutic implications.
Structured PICO
Does acute myocardial ischemia induced by coronary spasm or rapid atrial pacing activate the coagulation system and platelet activation in the coronary circulation?
P
Population
45 patients: 15 with coronary spastic angina, 15 with stable exertional angina, and 15 controls with chest pain but normal coronary arteries and no coronary spasm.
I
Intervention
Intracoronary injection of acetylcholine to induce coronary spasm (in coronary spastic angina group) or rapid atrial pacing to induce acute myocardial ischemia (in stable exertional angina group).
C
Comparator
Intracoronary injection of acetylcholine in patients with chest pain but normal coronary arteries (control group).
O
Outcome
Coronary sinus-arterial difference of plasma fibrinopeptide A and beta-thromboglobulin levels before and after induced ischemia or spasm.surrogate
Coronary spasm, but not pacing-induced ischemia, induces thrombin generation in the coronary circulation, suggesting a mechanism for thrombus formation in vasospastic angina.
Cite This Study
Hori-Oshima et al. (1990) studied this question.