ALECT2 Amyloidosis of the Spleen With Concurrent Pancreatic Amyloid Deposition Incidentally Identified in a Patient With Symptomatic Mucinous Cystadenoma

This is the authors' abstract. We don't add key points for this paper.

ALECT2 amyloidosis is a systemic form of amyloid deposition that most often involves the kidneys and liver and is frequently identified incidentally on surgical pathology.Splenic involvement is relatively common, whereas pancreatic deposition is rare, and both are typically asymptomatic.A woman in her early 60s presented with right flank and left upper abdominal pain and was found to have a 7-cm cystic lesion in the pancreatic tail.She underwent laparoscopic distal pancreatectomy and splenectomy, and pathology revealed a multiloculated mucinous cystadenoma involving both organs.Congo red staining demonstrated amyloid deposition in the pancreas and spleen.Mass spectrometry confirmed ALECT2 amyloid in the spleen.Postoperative evaluation showed no evidence of systemic involvement.The patient recovered well following surgery.This case highlights that ALECT2 amyloid identified in the spleen or pancreas is usually incidental and that accurate amyloid typing is essential to guide management and avoid unnecessary therapy.