Key result
Levothyroxine reverses impaired left ventricular systolic function and increases ECG wave amplitudes in hypothyroid dogs.
Echocardiograms and ECG were obtained for 11 hypothyroid dogs before and after levothyroxine supplementation (0.022 mg/kg of body weight, q 12 h for 64 +/- 12 days). Evidence of impaired left ventricular function was found in the dogs before treatment. A significant decrease in shortening fraction and velocity of circumferential fiber shortening, increase in left ventricular end-systolic diameter, and prolongation of preejection period was noted when comparing measurements before and after levothyroxine supplementation. Amplitude of the P and R waves was significantly higher after treatment than before. It was concluded that changes in cardiac function can be reversed in hypothyroid dogs.
No takes yet. Share an insight, caveat, or question.
David L. Panciera (1994) studied Hypothyroidism in dogs (n=11). Levothyroxine supplementation vs. Pre-treatment baseline was evaluated on Echocardiographic and electrocardiographic measures of left ventricular function (shortening fraction, velocity of circumferential fiber shortening, LV end-systolic diameter, preejection period, P and R wave amplitudes). Levothyroxine (0.022 mg/kg q12h for 64±12 days) in 11 hypothyroid dogs reversed impaired left ventricular function and increased P and R wave amplitudes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: