Role of hyperhomocysteine, thyroid dysfunction and their interaction in ischemic stroke patients with non-valvular atrial fibrillation

The role of hyperhomocysteinemia (HHcy) and thyroid dysfunction in ischemic stroke with non-valvular atrial fibrillation (AF) remains controversial. Till now, the relationship between HHcy and thyroid dysfunction in ischemic stroke with non-valvular AF has not been reported. The aim of this study was to investigate the role and relationship of HHcy and thyroid dysfunction in ischemic stroke patients with non-valvular AF. Seven hundred and seventeen patients with acute ischemic stroke within the first 7 days of symptom onset were consecutively included in this study. Eligible patients were divided into AF group and without AF group. Variables including age, sex, smoke, drink, history of stroke were collected. Levels of homocysteine (Hcy), thyroid-stimulating hormone were evaluated at presentation. Multivariable logistic regression and spearman bivariate correlate analysis were used to evaluate the relationship of HHcy and thyroid dysfunction in ischemic stroke patients with AF. There were 122 patients with AF and 595 patients without AF. Two hundred and eighty-eight (40.2%) patients had HHcy and Three hundred and sixteen (44.1%) patients had thyroid dysfunction. There was significant difference of serum Hcy (P = 0.014) and thyroxine levels (P = 0.002) between patients with and without AF. Furthermore, the difference of serum Hcy (P = 0.007) and thyroxine levels (P = 0.004) between patients with and without AF was also significant in female subgroups. We did not find association between HHcy and thyroid dysfunction in AF group (P = 0.463). In conclusion, both HHcy and thyroid dysfunction were associated with AF in patients with acute ischemic stroke and in female subgroup patients. However, thyroid dysfunction had no relationship with HHcy in ischemic stroke patients with AF.