On Predicting the Concentration of Diclofenac Drug in the Body Compartments and Dosage Over Time Using Numerical Method

Predicting the concentration of diclofenac drug in the body compartments and its response to dosage over time at time intervals 5:5:60 and 60:5:115 has been considered using MATLAB24.2. From the results output, we observed that at an interval of five (5) minutes up to fifty five (55mins), showed that at the initial time of administering the dosage, the concentration (the active mass) of diclofenac in stomach compartment is observed to be zero when the time was five (5) minutes the concentration that was being used up was 0.1943ml/dm3 and the volume of solvent was 6.995281 units. Also, when the time ranges from ten (10) minutes to fifty five (55) minutes, the concentration decreased down the trend from a value of 0.167156ml/dm3 up to a value of 0.119173 ml/dm3 when the time was fifty five minutes whereas the solvent in the stomach compartment ranges from 8.692112 to 23.357951units. Furthermore, when the time ranges from sixty (60) minutes up to one hundred and fifteen (115) minutes, the active mass of diclofenac drug that was being used up decreased down the trend from a value of 0.117902 ml/ dm3 up to a value of 0.110637 ml/ dm3 when the time is one hundred and fifteen (115) minutes whereas the volume of solvent containing the drug mixture in the stomach compartment ranges from 24.995253 at the sixty five (65) minutes, and increases down the trend up to 42.927294 units at one hundred and fifteen (115) minutes. This observation is normal with the usual medical practice and serves as a guide for a proper monitoring of a patient by a physician for its response to dosage and the active component of the diclofenac drug at the specific time. The full results and discussion are presented in this study.