Key result
Polymyositis on long-term prednisolone links to persistently elevated CK-MB and cTnT without myocardial injury.
Why the study?
Interpreting elevated CK-MB and cardiac troponin T levels as evidence of myocardial injury in patients with chronic muscle degeneration such as polymyositis requires caution.
Case Report (n=1)
No
Elevated CK-MB and cTnT warrant caution against assuming myocardial injury in polymyositis; supports skeletal muscle source in inflammatory myopathies.
From an extensive model developed to interpret physiological processes we are able to show that the observed elevated creatine kinase-myoglobin (CK-MB) and serum concentration of cardiac troponin T (cTnT) values for a particular patient are associated with the inflammatory disease, polymyositis, and not myocardial injury. This highlights that caution must be exercised in using elevated CK-MB and cTnT levels as evidence for myocardial damage in patients with chronic muscle degeneration such as polymyositis.
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GOLDING et al. (2008) conducted a case report in Polymyositis (n=1). Prednisolone (with trandolapril and Ambrotose) was evaluated on Serum creatine kinase-MB (CK-MB) and cardiac troponin T (cTnT) concentrations. Polymyositis under long-term prednisolone therapy was associated with persistently elevated, time-independent CK-MB (15.90±2.38 IU/L) and cTnT (0.14±0.02 IU/L) levels without myocardial injury.
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