Immunization schedules are based on extensive safety and efficacy research. Clinical trials and population-based research are used to determine optimal schedules for immunization to prevent serious and potentially fatal diseases. Changes to the Centers for Disease Control and Prevention recommended vaccination schedule made in 2025 and 2026 were not evidence-based and are no longer supported by professional organizations. The CDC recommendations formerly referenced here have now been replaced by recommended schedules from the American Academy of Pediatrics and the American Academy of Family Physicians.
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Derek Tam (2026) studied this question.
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