Key result
Shenxinning Decoction improves cardiac remodeling and renal function parameters in cardiorenal mice.
Why the study?
The efficacy of Shenxinning Decoction (SXND) on ventricular remodeling in AT1 receptor-knockout (AT1-KO) mice with chronic renal insufficiency (CRI) needed to be observed.
Should not change clinical practice in cardiorenal disease; hypothesis-generating for AT1-independent effects of Shenxinning Decoction.
OBJECTIVE: To observe the efficacy of Shenxinning Decoction (SXND) in ventricular remodeling in AT1 receptor-knockout (AT1-KO) mice with chronic renal insufficiency (CRI). MATERIALS AND METHODS: AT1-KO mice modeled with subtotal (5/6) nephrectomy were intervened with SXND for 12 weeks. Subsequently, blood urea nitrogen (BUN), serum creatinine (SCr), brain natriuretic peptide (BNP), echocardiography (left ventricular end-diastolic diameter, LVDD; left ventricular end-systolic diameter, LVDS; fractional shortening, FS; and ejection fraction, EF), collagen types I and III in the heart and kidney, myocardial mitochondria, and cardiac transforming growth factor-β1 (TGF-β1) of the AT1-KO mice were compared with the same model with nephrectomy only and untreated with SXND. RESULTS: AT1-KO mice did not affect the process of CRI but it could significantly affect cardiac remodeling process. SXND decreased to some extent the AT1-KO mice's BUN, SCr, BNP, and cardiac LVDD, LVDS, and BNP, improved FS and EF, lowered the expression of collagen type I and III in heart and kidney, increased the quantity of mitochondria and ameliorated their structure, and down-regulated the expression of TGF-β1. CONCLUSION: SXND may antagonize the renin-angiotensin system (RAS) and decrease uremia toxins, thereby ameliorating ventricular remodeling in CRI. Furthermore, SXND has a mechanism correlated with the improvement of myocardial energy metabolism and the down-regulation of TGF-β1.
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Zhou et al. (2014) studied Chronic renal insufficiency with ventricular remodeling (n=47). Shenxinning Decoction (SXND) vs. Untreated 5/6 nephrectomy models (wild-type and AT1-KO) and pseudosurgery control was evaluated on Ventricular remodeling and renal function parameters (BUN, SCr, BNP, LVDD, LVDS, FS, EF, cardiac/renal collagen types I and III, and cardiac TGF-β1) (p=<0.05). Shenxinning Decoction significantly reduced BUN, SCr, BNP, LVDD, LVDS, collagen I/III, and TGF-β1 while improving EF and FS (all P<0.05) in AT1-KO mice with chronic renal insufficiency.
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