Key result
Doppler renal arterial velocities correlate strongly with creatinine clearance in chronic glomerulonephritis.
Why the study?
The utility of Doppler sonographic measurement of phasic renal artery blood flow velocity at the renal hilus for evaluating renal function in patients with chronic glomerulonephritis needed investigation, as absolute blood flow velocity had previously been difficult to determine.
Cross-Sectional (n=103)
Renal Doppler velocities may aid noninvasive monitoring in glomerulonephritis; leaves open prospective validation against clinical outcomes.
The phasic arterial blood flow velocity at the renal hilus was measured by Doppler sonography in 25 healthy subjects and 78 patients with chronic glomerulonephritis. Doppler velocity waveform was analyzed to give peak systolic velocity (S), end-diastolic velocity (D), resistive index (RI), and pulsatility index (PI). Creatinine clearance correlated with S (r = 0.76), D (r = 0.80), RI (r = -0.74), and PI (r = -0.85). Color Doppler sonography facilitated the detection of blood flow and permitted the measurement of absolute blood flow velocity, which previously had been difficult to determine. These results suggest that renal arterial blood flow as detected by Doppler ultrasonography may be useful for noninvasive, direct, rapid, and simple evaluation of renal function, although various modifying factors also need to be considered.
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Yura et al. (1993) conducted a cross-sectional in Chronic glomerulonephritis (n=103). Doppler sonography of phasic renal artery blood flow velocity vs. Healthy subjects / creatinine clearance reference was evaluated on Correlation between creatinine clearance and Doppler velocity waveform parameters (peak systolic velocity [S], end-diastolic velocity [D], resistive index [RI], and pulsatility index [PI]) (r = 0.76 (S), r = 0.80 (D), r = -0.74 (RI), r = -0.85 (PI)). Doppler-measured renal arterial velocities correlated strongly with creatinine clearance in chronic glomerulonephritis, including peak systolic (r=0.76), end-diastolic (r=0.80), RI (r=-0.74), and PI (r=-0.85).
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