Key result
Prehabilitation before thoracic surgery improves functional capacity, but evidence for reducing complications remains fragile.
Why the study?
Prehabilitation is increasingly used before noncardiac thoracic surgery to increase physiological reserve, but whether improved functional capacity translates into better postoperative outcomes remains uncertain.
Does prehabilitation improve functional capacity and postoperative outcomes in patients undergoing noncardiac thoracic surgery?
Does prehabilitation improve functional capacity and postoperative outcomes in patients undergoing noncardiac thoracic surgery?
Prehabilitation before noncardiac thoracic surgery improves functional capacity, but given trial heterogeneity and fragility of complication outcomes, a risk-adapted approach integrated with early postoperative rehabilitation is preferable to universal implementation.
May support risk-adapted prehabilitation in thoracic surgery; leaves open complication benefits pending larger homogeneous trials.
Purpose of review Prehabilitation is increasingly used before thoracic surgery to increase physiological reserve, but whether improved functional capacity translates into better postoperative outcomes remains uncertain. This review examines the physiological rationale, recent evidence, and appropriate role of prehabilitation in noncardiac thoracic surgery. Recent findings Preoperative exercise and multimodal programs consistently improve functional capacity, including 6-min walk distance and cardiopulmonary fitness. Thoracic-specific meta-analyses suggest reductions in postoperative pulmonary complications and hospital stay; however, individual randomized trials remain heterogeneous, and a recent fragility analysis of prehabilitation trials in cancer surgery showed that statistically positive complication outcomes typically hinged on a single event. Functional improvement does not necessarily mediate reductions in complex postoperative morbidity, and similar medium-term recovery may be achievable with postoperative rehabilitation. Optimal patient selection remains uncertain. Summary Prehabilitation can increase physiological reserve, but it cannot neutralize the multidimensional stress of major noncardiac thoracic surgery. A risk-adapted approach is preferable to universal implementation. Prehabilitation should exploit an existing oncologically acceptable waiting period, avoid delaying definitive surgery, and be integrated with early postoperative rehabilitation.
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Donatelli et al. (2026) conducted a review in Major noncardiac thoracic surgery. Preoperative exercise and multimodal prehabilitation programs was evaluated on Postoperative pulmonary complications, hospital stay, and functional capacity (6-minute walk distance, cardiopulmonary fitness). Prehabilitation before thoracic surgery improves 6-minute walk distance and fitness, though randomized trials remain heterogeneous and positive complication outcomes often hinge on 1 event.
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