Key result
Abdominal visceral adipose tissue is linked to ~6% higher odds of carotid atherosclerosis.
Why the study?
Visceral obesity is an important marker of cardiometabolic risk, but data on the association between ultrasound-assessed regional adipose tissue distribution and subclinical atherosclerosis in the Kyrgyz ethnic group were lacking.
Are ultrasound parameters of visceral and subcutaneous adipose tissue associated with carotid atherosclerosis in adults of the Kyrgyz ethnic group?
Cross-Sectional (n=108)
No
Are ultrasound parameters of visceral and subcutaneous adipose tissue associated with carotid atherosclerosis in adults of the Kyrgyz ethnic group?
In a Kyrgyz ethnic cohort, ultrasound-measured abdominal and renal visceral adipose tissue thickness—but not subcutaneous adipose tissue—were independently associated with subclinical carotid atherosclerosis.
Ultrasound VAT thickness was associated with carotid atherosclerosis; extends visceral adiposity evidence to Kyrgyz adults but remains hypothesis-generating.
Background. Visceral obesity is a more important marker of cardiometabolic risk than overall adiposity or subcutaneous fat accumulation. However, there are no data on association between ultrasound-assessed regional adipose tissue distribution and subclinical atherosclerosis in the Kyrgyz ethnic group. Objective. To assess association of ultrasound parameters of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with carotid atherosclerosis (CA) in the Kyrgyz ethnic group. Material and methods. A cross-sectional analytical observational study included 108 respondents aged 19—65 years who attended a cardiology clinic for preventive evaluation. Demographic and behavioral risk factors, anthropometric parameters, blood pressure, glucose and lipid metabolism with calculation of HOMA-IR, ultrasound parameters of VAT and SAT, and carotid artery ultrasound data were assessed in all participants. Associations between ultrasound parameters and CA were analyzed using binary logistic regression. Results. CA was detected in 26 out of 108 participants. In between-group comparisons, all ultrasound parameters of VAT and SAT were higher in individuals with CA. In addition, ultrasound parameters of adipose tissue were associated with adverse cardiometabolic profile, including anthropometric obesity measures, blood pressure, insulin resistance, and markers of metabolic liver injury. After multivariable adjustment, only abdominal VAT thickness (odds ratio 1.056; 95% confidence interval 1.007—1.107; p=0.025) and renal VAT thickness (odds ratio 1.107; 95% confidence interval 1.022—1.199; p=0.013) remained independently associated with CA. SAT parameters were not associated with CA. In ROC analysis, abdominal VAT ≥33.5 mm and renal VAT ≥19 mm showed high sensitivity and moderate specificity for CA. Conclusion. In this cohort, greater abdominal and renal VAT thickness was independently associated with CA, whereas SAT parameters did not demonstrated these correlations.
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Polupanov et al. (2026) conducted a cross-sectional in Carotid artery atherosclerosis (n=108). Ultrasound-assessed visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) thickness vs. Lower adipose tissue thickness / absence of carotid atherosclerosis was evaluated on Carotid atherosclerosis (CA) (OR 1.056 (abdominal VAT); OR 1.107 (renal VAT), 95% CI 1.007-1.107, p=0.025). Abdominal VAT (OR 1.056, 95% CI 1.007-1.107; p=0.025) and renal VAT thickness (OR 1.107, 95% CI 1.022-1.199; p=0.013) were independently associated with carotid atherosclerosis.
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