Key result
Higher systolic blood pressure correlates with nocturia severity and nocturnal urine volume in adolescents.
Why the study?
While nocturia is associated with systolic BP hypertension in adults, diastolic BP has greater relative importance in youth, and little is known about the hemodynamic profile of the hypertension-nocturia link in adolescents.
Do brachial artery systolic and diastolic blood pressures and central aortic pressures correlate with nocturia severity in adolescents aged 10–18 years?
Cross-Sectional (n=100)
Yes
Do brachial artery systolic and diastolic blood pressures and central aortic pressures correlate with nocturia severity in adolescents aged 10–18 years?
Effect estimate: r = 0.27
p-value: p=0.007
In adolescents, systolic blood pressure (both brachial and central), rather than diastolic blood pressure, is independently associated with nocturia severity, nocturnal urine volume, and production rate.
May prompt BP evaluation in nocturic adolescents; extends adult SBP links but remains hypothesis-generating.
Nocturia, defined as waking to void during sleep hours, is common in adolescents, causing sleep disruption and daytime fatigue. While numerous studies have found nocturia associated with systolic blood pressure (BP) hypertension in adults, diastolic (D) BP has greater relative importance in youth. Little is known about the hemodynamic profile of the hypertension–nocturia link in adolescents. Accordingly, we evaluated relationships between nocturia severity and brachial artery systolic and DBPs in each arm, as well as central aortic pressures using applanation tonometry. We studied 100 adolescents, 10–18 years, from pediatric clinics. Nocturnal urinary indices were obtained from voiding diaries. Results: In total, 45% reported nocturia. Nocturia severity was correlated with left and right arm brachial SBP, higher of two arms, and central SBP (r = 0.27, p = 0.007). Brachial SBP was also correlated with nocturnal urine volume (NUV) (r = 0.31, p = 0.001) and production rate (NUP) (r = 0.32, p = 0.001). DBP showed no significant correlations. After adjusting for BMI and sex, brachial SBP remained independently associated with nocturia severity. The median first uninterrupted sleep period was 171 min (25–75%ile; 94, 300). In adolescents, SBP is associated with nocturia severity, NUV, and NUP. Nocturia typically occurs during the first half of nighttime, suggesting an impact on deep sleep.
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Promi et al. (2026) conducted a cross-sectional in Nocturia (n=100). Brachial and central aortic blood pressure was evaluated on Nocturia severity, nocturnal urine volume (NUV), and nocturnal urine production rate (NUP) (r = 0.27, p=0.007). Systolic blood pressure correlated with nocturia severity (r=0.27, p=0.007) and nocturnal urine volume (r=0.31, p=0.001) in adolescents, whereas diastolic BP showed no significant correlation.
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