October 23, 2025Hypertension1 citations
View Full PaperEffect of Nocturia and Sleep Quality on Sleep Blood Pressure: The HI-JAMP Study
Key Result
Nocturia frequency of ≥3 voids was associated with a 9.6 mm Hg increase in nighttime systolic BP and an 8.5 mm Hg increase in sleep systolic BP (P<0.001 for both).
Study Design
Type
Observational (n=1,252)
Structured PICO
Do nocturia and poor sleep quality increase sleep blood pressure in hypertensive patients?
P
Population
1,252 hypertensive patients taking at least 1 antihypertensive agent, mean age 67.4 years, 58.2% male, from the HI-JAMP study in Japan.
I
Intervention
Nocturia frequency and self-reported poor sleep assessed via self-report diary during a 24-hour ambulatory BP monitoring night.
C
Comparator
Patients with no nocturia or good sleep quality.
O
Outcome
Nighttime blood pressure (measured between self-reported sleep and awakening times) and sleep blood pressure (BP without physical activity during a sleep period).surrogate
Nocturia has a significant impact on increasing blood pressure during sleep in hypertensive patients, independent of physical activity.
Main Result
p-value: p=<0.001
Abstract
BACKGROUND: Blood pressure (BP) during sleep is known to be affected by sleep disturbance, including nocturia and sleep disorders. This study investigated the effect of nocturia and self-reported poor sleep on BP using a multisensor BP monitoring device (TM-2441; A mean body mass index, 24.8±3.9 kg/m 2 ; 58.2% male) were analyzed. Averages of sleep systolic BP (SBP) were lower than those of nighttime SBP (113.9±15.8 versus 115.2±15.5 mm Hg; P <0.001). Frequency of nocturnal voids was associated with an increase in nighttime systolic SBP (1–2×: 4.7 mm Hg, P <0.001; ≥3×: 9.6 mm Hg, P <0.001) and sleep SBP (1–2×: 4.1 mm Hg, P <0.001; ≥3×: 8.5 mm Hg, P <0.001). Self-reported poor sleep showed a marginal association with increased nighttime SBP but was not associated with sleep SBP. CONCLUSIONS: Compared with self-reported poor sleep, nocturia had a greater impact on BP during sleep, even after excluding BP readings with nocturnal physical activity. REGISTRATION: https://www.umin.ac.jp ; Unique identifier: UMIN000029151.