Influenza Immunization in Lupus Erythematosus: Safe, Effective?

Editorials1 June 1978Influenza Immunization in Lupus Erythematosus: Safe, Effective?EVELYN V. HESS, M.D., F.A.C.P., BEVRA HAHN, M.D.EVELYN V. HESS, M.D., F.A.C.P., BEVRA HAHN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-6-833 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe threat of a swine influenza epidemic in 1976 reawakened interest in influenza immunization in patients with immunologic disorders such as systemic lupus erythematosus and other connective tissue diseases. Could these patients safely receive foreign viral antigens without a worsening of their disease? Would the vaccine be effective in these patients? The 1976 National Influenza Immunization Program gave investigators the opportunity to answer these important questions.The survival of patients with systemic lupus erythematosus has markedly improved in recent years. In 1953, approximately 20% of patients were alive after 5 years; recent studies estimate survival of 80% to 90% at...References1. FRIESHOLMAN JJ: Systemic Lupus Erythematosus, vol. VI in Major Problems in Internal Medicine. Philadelphia, W.B. Saunders, 1975 Google Scholar2. STAPLESGERDINGDECKERGORDON PDJR: Incidence of infection in systemic lupus erythematosus. Arthritis Rheum 17:1-10, 1974 CrossrefMedlineGoogle Scholar3. BRODMANGILFILLANGLASSSCHUR RRDP: Influenzal vaccine response in systemic lupus erythematosus. Ann Intern Med 88:735-740, 1978 LinkGoogle Scholar4. LOUIENIESSHOJIFRABACKABRASSBORDERCHERRYIMAGAWA JKKRCWJD: Clinical and antibody responses after influenza immunization in systemic lupus erythematosus. Ann Intern Med 88:790-792, 1978 LinkGoogle Scholar5. RISTOWDOUGLASCONDEMI SRJ: Influenza vaccination of patients with systemic lupus erythematosus. Ann Intern Med 88:786-789, 1978 LinkGoogle Scholar6. WILLIAMSSTEINBERGREINERTSENKLASSENDECKERDOLIN GAJLJR: Influenza immunization in systemic lupus erythematosus: a double blind trial. Ann Intern Med 88:729-734, 1978 LinkGoogle Scholar7. COHENREYNOLDSFRANKLINKULKAROPESSHULMANWALLACE AWEJMLS: Preliminary criteria for the classification of systemic lupus erythematosus. Bull Rheum Dis 21:643-648, 1971 Google Scholar8. DEHORATIUSMESSNER RR: Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus. J Clin Invest 55:1254-1258, 1975 CrossrefMedlineGoogle Scholar9. STEVENSARNETTDORSCHSUTTONZIZICSCHMIDTPOTOTSKY MFCJTMR: Antibody response to viral antigens in systemic lupus and rheumatoid arthritis (abstract). ARA Southeast Scientific Meeting, December 1977 Google Scholar10. HERRONBRANDWINDETTLEFFHAHN ALGB: Influenza vaccination of patients with rheumatic diseases (abstract). Proc XIV Int Congress Rheum, June 1977 Google Scholar11. HAUPTMANTOMASI ST: The secretory immune system, in Basic and Clinical Immunology, edited by FUDENBERG HH. LOS Altos, California, Lange, 1976 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. 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FRED AYVAZIAN, M.D. 1 June 1978Volume 88, Issue 6Page: 833-834KeywordsAntigensConnective tissue diseasesLupus erythematosusSwine influenzaVaccinesViral diseases Issue Published: 1 June 1978 PDF DownloadLoading ...