Leuko‐Glycemic Index Is Associated With Extubation Failure in Myasthenic Crisis: A Retrospective Cohort Study

Objectives The aim of this study was to investigate the association between the Leuko‐Glycemic Index (LGI) and extubation failure in patients with myasthenic crisis (MC) and to explore related clinical and laboratory factors. Methods This retrospective cohort study included 62 patients with myasthenic crisis who required mechanical ventilation at the First Affiliated Hospital of Nanchang University between January 2018 and December 2024. Clinical and laboratory data were retrospectively collected. Logistic regression analysis was used to examine factors associated with extubation failure, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminative performance of the leuko‐glycemic index. Results Among the 62 included patients, 30 (48.4%) experienced extubation failure. Patients with extubation failure had significantly higher LGI values than those with successful extubation (1.57 vs. 1.08, p = 0.001). In multivariate logistic regression analysis, LGI remained independently associated with extubation failure (OR = 3.223, 95% CI: 1.062–9.777; p = 0.039). Receiver‐operating characteristic analysis showed moderate discriminative ability for LGI (AUC = 0.729), with higher overall performance observed for the multivariate model (AUC = 0.841). Conclusions Higher LGI was associated with extubation failure in patients with myasthenic crisis and may provide additional information for identifying patients at increased risk of extubation failure.