Why the study?
Substantial controversy exists regarding the definition, classification, and staging of cardiac adenocarcinoma, alongside a recently documented shift from distal to proximal lesions in gastric cancer.
Cohort (n=78)
No
Answers are grounded in this paper and cite their sources.
Reveals lower survival and advanced staging in cardiac adenocarcinoma versus distal gastric cancer, indicating delayed presentation impairs surgical outcomes.
BACKGROUND AND OBJECTIVES: There is a great deal of controversy regarding the definition, classification, and staging of cardiac adenocarcinoma (CA). Recently, a shift from distal to proximal lesions has been documented in gastric cancer. We have stratified our cases of gastric cancer as CA, distal gastric cancer (DGC), and stump cancer (SC). METHODS: Between 1986 and 1998, 450 patients with gastric cancer were operated on at our institute. The resectability rate was 81.6%. Of 367 patients, 48 were CA, 298 DGC, and 21 SC. These 3 groups were compared in terms of clinicopathologic factors and survival rates. RESULTS: CA was significantly higher in male patients and showed a prevalence of the Lauren intestinal type. Regarding staging parameters, CA showed a higher rate of T3 tumors and of resection line involvement. Five-year survival rates were 23. 2% for CA, 45.0% for DGC, and 17.4% for SC. CONCLUSIONS: A possible cause of the poor outcome of CA is presentation at a more advanced stage. CA was similar to SC as far as epidemiology, pathologic factors, and survival rates.
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Bruno et al. (2000) conducted a cohort in Gastroesophageal junction adenocarcinoma (n=78). Coexistence of hiatal hernia (Makuuchi Grade A-C) vs. Absence of hiatal hernia (Makuuchi Grade D) was evaluated on Overall survival in cT3-4 gastroesophageal junction cancer (multivariate analysis) (HR 3.60, 95% CI 1.06-11.9, p=0.032).
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