Key result
Higher post-PCI cardiac power is linked to ~32% lower adverse outcome risk per 0.1 W.
Why the study?
The prognostic role of cardiac power in relation to the infarct-related artery and contemporary echocardiographic parameters after acute MI remained incompletely defined.
Does early post-revascularization cardiac power measurement predict left ventricular dysfunction and 6-month adverse clinical outcomes in patients with acute myocardial infarction undergoing percutaneous coronary intervention?
Cohort (n=99)
Does early post-revascularization cardiac power measurement predict left ventricular dysfunction and 6-month adverse clinical outcomes in patients with acute myocardial infarction undergoing percutaneous coronary intervention?
Early measurement of cardiac power 24–48 hours after PCI for acute MI independently predicts left ventricular dysfunction and 6-month adverse clinical outcomes.
May refine post-MI risk stratification after PCI; leaves open additive value to LVEF in prospective validation.
Background Cardiac power (CP), calculated from mean arterial pressure and cardiac output, reflects global cardiac pumping capability. Its prognostic role in relation to infarct-related artery and contemporary echocardiographic parameters after acute myocardial infarction (MI) remains incompletely defined. Purpose To determine whether early post-revascularization CP predicts left ventricular (LV) dysfunction and adverse clinical outcomes at 6 months following acute MI. Methods In this prospective study, 99 consecutive patients with acute MI undergoing percutaneous coronary intervention were enrolled. CP was measured 24–48 hours post-procedure. LV ejection fraction (LVEF) and global longitudinal strain (GLS) were assessed by transthoracic echocardiography. Patients were followed for 6 months. The primary adverse outcome was a composite of “Very low” or “Bad” clinical status at 3 or 6 months, based on a pre-specified scale integrating symptoms, functional class, and echocardiographic findings. Multivariable linear and logistic regression models adjusted for age, sex, Killip class, and time to revascularization. Discriminative performance was assessed using receiver operating characteristic (ROC) analysis. Results Patients with left anterior descending (LAD) culprit artery had lower CP compared with non-LAD infarctions (0.76±0.19 vs 0.91±0.24 W, p<0.001). CP correlated with LVEF (r=0.59, p<0.001) and GLS (r=0.64, p<0.001). CP remained independently associated with LVEF (β=2.3 per 0.1 W, p<0.001) and GLS (β=−0.8 per 0.1 W, p<0.001). Eighteen patients (18.2%) experienced adverse outcomes and had lower baseline CP than event-free patients (0.62±0.15 vs 0.86±0.21 W, p<0.001). CP independently predicted adverse outcomes (OR 0.68 per 0.1 W, p<0.001). ROC analysis showed AUC 0.82 for predicting LVEF <40% and 0.80 for adverse outcomes. CP improved from baseline to 6 months (0.82±0.23 to 0.90±0.20 W, p<0.001), with attenuated recovery in patients with adverse outcomes (interaction p=0.04). Conclusions Early cardiac power measurement after acute MI independently predicts LV dysfunction and 6-month adverse clinical outcomes. CP provides integrated hemodynamic information beyond conventional parameters and may assist in early risk stratification.
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Merry et al. (2026) conducted a cohort in Acute myocardial infarction undergoing percutaneous coronary intervention (n=99). Early post-revascularization cardiac power (measured 24–48 hours post-PCI) was evaluated on Composite of 'Very low' or 'Bad' clinical status at 3 or 6 months, based on a pre-specified scale integrating symptoms, functional class, and echocardiographic findings (OR 0.68 per 0.1 W, p=<0.001). Early post-PCI cardiac power independently predicted 6-month adverse clinical outcomes after acute MI (OR 0.68 per 0.1 W, p<0.001; AUC 0.80) and LVEF <40% (AUC 0.82).
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