Is Concomitant Mitral Regurgitation With Severe Aortic Stenosis Benign or Malignant?

However, mitral valve (MV) interventions were not or rarely performed in those studies.Increased mortality was also noted in patients with significant MR who underwent TAVR compared with those without MR 5-7 in whom no MV interventions were done.Thus, due to the lack of sufficient interventions for concomitant MR in patients with severe AS reported in the published literature, its effect in severe AS remains elusive.In this issue of the Journal, Murai and colleagues 8 demonstrate that concomitant moderate/severe MR is not independently associated with a high risk of the composite endpoint of heart failure hospitalization and aortic valve-M oderate/severe mitral regurgitation (MR) is a common coexistent disorder in patients with severe aortic stenosis (AS).Because MR may develop in the presence of high ventricular pressure due to severe AS, the frequency of significant MR increases as the severity of AS increases.Therefore, assessment for significant MR complicated with severe AS in need of invasive treatment is never a negligible issue in daily practice.Previous studies 1-7 have examined the effect of significant MR concomitant with severe AS on mortality, mainly in patients undergoing invasive procedures such as surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR).Most studies, including meta-analyses, focusing on SAVR have shown increased mortality in patients with significant MR compared with those without MR.1-4