Key result
Moderate or greater MR in moderate AS linked to ~86% higher CV death or HF hospitalization.
Why the study?
Patients with moderate AS and concomitant MR often present with symptoms despite neither lesion reaching intervention thresholds, but the clinical impact of this dual valvular disease remains a knowledge gap.
Does concomitant moderate or greater mitral regurgitation increase the risk of cardiovascular death or heart failure hospitalization in patients with moderate aortic stenosis?
Cohort (n=742)
Does concomitant moderate or greater mitral regurgitation increase the risk of cardiovascular death or heart failure hospitalization in patients with moderate aortic stenosis?
In patients with moderate aortic stenosis, concomitant moderate or greater mitral regurgitation identifies a high-risk phenotype associated with adverse remodeling and significantly increased risk of cardiovascular death or heart failure hospitalization.
Answers are grounded in this paper and cite their sources.
Coexisting moderate or greater MR in moderate AS signals higher event risk; leaves open whether MR correction improves outcomes.
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Gabr et al. (2026) conducted a cohort in Moderate aortic stenosis with concomitant mitral regurgitation (n=742). Concomitant moderate or greater mitral regurgitation vs. Isolated moderate aortic stenosis was evaluated on Cardiovascular death or heart failure hospitalization (HR 1.86, 95% CI 1.31-2.65, p=<0.001). Concomitant moderate or greater mitral regurgitation in moderate aortic stenosis increased the risk of cardiovascular death or heart failure hospitalization.
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