Key result
Moderate AS with moderate AR linked to ~49% higher cardiac risk than moderate AS alone.
Why the study?
Mixed aortic valve disease poses unique haemodynamic challenges, leading to this comparison of clinical outcomes between concomitant moderate aortic stenosis and moderate aortic regurgitation versus isolated aortic stenosis.
Does moderate aortic stenosis with concomitant moderate aortic regurgitation worsen clinical outcomes compared to isolated moderate or severe aortic stenosis in patients with valvular heart disease?
Does moderate aortic stenosis with concomitant moderate aortic regurgitation worsen clinical outcomes compared to isolated moderate or severe aortic stenosis in patients with valvular heart disease?
Moderate aortic stenosis with concomitant moderate aortic regurgitation is not a benign condition and is associated with poor clinical outcomes comparable to those of isolated severe aortic stenosis.
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Moderate ASR was associated with worse outcomes than moderate AS alone; leaves open whether mixed disease warrants earlier intervention.
Son et al. (2025) studied this question. Moderate AS with moderate aortic regurgitation increases risk of cardiac death or heart failure hospitalization by 49% versus moderate AS alone, similar to severe AS risk.
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