Key result
In patients with moderate aortic stenosis, moderate or moderate-to-severe mitral regurgitation was independently associated with adverse clinical outcomes (HR 4.84; 95% CI 1.66-10.07).
Why the study?
Clinical outcomes of moderate aortic stenosis with comorbidity have not been extensively studied, though surgical correction can currently be deferred with watchful waiting.
Cohort (n=148)
Hazard Ratio: 4.84 (95% CI 1.66–10.07)
Symptomatic patients with moderate aortic stenosis and comorbidities such as diabetes mellitus or moderate-to-severe mitral regurgitation have high rates of adverse events, suggesting a potential benefit for early intervention.
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Moderate MR in moderate AS was associated with worse outcomes; leaves open whether early intervention improves prognosis.
Bae et al. (2020) conducted a cohort in Moderate aortic stenosis (n=148). Moderate or moderate-to-severe functional mitral regurgitation (MR) was evaluated on Composite of cardiovascular (CV) death, admission for heart failure (HF) aggravation, and AV replacement (HR 4.84, 95% CI 1.66-10.07). In patients with moderate aortic stenosis, moderate or moderate-to-severe mitral regurgitation was independently associated with adverse clinical outcomes (HR 4.84; 95% CI 1.66-10.07).
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