Key result
Patients with moderate aortic stenosis face a significant risk of death, with a 5-year overall survival of only 52.3% and an incidence of 12.6 deaths per 100 person-years.
Why the study?
The natural history of patients with moderate aortic stenosis is poorly understood.
Population
729 patients with echocardiography-defined moderate aortic stenosis
Design
Observational cohort study
Follow-up
Median 5.0 years
Authors
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High mortality in moderate aortic stenosis supports enhanced surveillance; leaves open whether earlier intervention improves survival in randomized trials.
Observational (n=729)
Yes
Patients with moderate aortic stenosis face a significant risk of death and heart failure hospitalization, highlighting the need to investigate earlier therapeutic interventions.
Du et al. (2021) conducted an observational in Moderate aortic stenosis (n=729). Moderate aortic stenosis vs. Expected survival of age- and sex-matched population was evaluated on 5-year overall survival (95% CI 48.6-56.0). Patients with moderate aortic stenosis face a significant risk of death, with a 5-year overall survival of only 52.3% and an incidence of 12.6 deaths per 100 person-years.
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