Moderate and severe aortic stenosis were associated with increased cardiovascular mortality compared to mild aortic stenosis (HR 1.47; 95% CI 1.07-2.02 and HR 3.66; 95% CI 2.52-5.31, respectively).
Why the study?
Modern data regarding the incidence and modes of death in patients with aortic stenosis are restricted to tertiary centers or studies of aortic valve replacement.
Does moderate or severe native aortic stenosis increase cardiovascular mortality compared to mild aortic stenosis in outpatients?
Population
2703 consecutive outpatients with mild, moderate, or severe native AS in France
Comparison
Moderate or severe AS vs mild AS
Design
Regionwide prospective cohort study
Follow-up
Median 2.1 years
Key result
Moderate and severe aortic stenosis were associated with increased cardiovascular mortality compared to mild aortic stenosis (HR 1.47; 95% CI 1.07-2.02 and HR 3.66; 95% CI 2.52-5.31, respectively).
Authors
Discussion
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Member takes
Overview
Real-world AS outpatients face high 5-year death or AVR rates; leaves open optimal surveillance and intervention timing in moderate disease.
Study Design
Type
Cohort (n=2,703)
Multicenter
Yes
Structured PICO
Does moderate or severe native aortic stenosis increase cardiovascular mortality compared to mild aortic stenosis in outpatients?
P
Population
2,703 outpatients with mild, moderate, or severe native aortic stenosis followed for a median of 2.1 years.
E
Exposure
Moderate or severe native aortic stenosis
C
Comparator
Mild native aortic stenosis
O
Outcome
Natural history, need for aortic valve replacement (AVR), and survival (cardiovascular mortality)hard clinical
Main Result
Hazard Ratio: 1.47 (95% CI 1.07–2.02)
Moderate aortic stenosis is associated with a slightly higher risk of cardiovascular death than mild AS in the general outpatient population, but this risk is similar to mild AS in asymptomatic patients.
Cite This Study
Coisne et al. (2021) conducted a cohort in Aortic stenosis (n=2,703). Moderate or severe aortic stenosis vs. Mild aortic stenosis was evaluated on Cardiovascular mortality (HR 1.47, 95% CI 1.07-2.02). Moderate and severe aortic stenosis were associated with increased cardiovascular mortality compared to mild aortic stenosis (HR 1.47; 95% CI 1.07-2.02 and HR 3.66; 95% CI 2.52-5.31, respectively).