Key result
24-hour ABPM increases nocturnal awakenings without altering total sleep time or efficiency.
Why the study?
The effects of ambulatory blood pressure measurement (ABPM) on sleep in depressed patients with near absence of deep (stage 3 and 4) sleep needed assessment.
RCT (n=12)
Crossover (random order on day 2 or 3)
Answers are grounded in this paper and cite their sources.
BACKGROUND: To assess the effects of ambulatory blood pressure measurement (ABPM) upon sleep in mentally depressed patients with near absence of deep (stage 3 and 4) sleep. METHODS: Twelve depressed patients aged 50.5+/-13.5 (21-item Hamilton Depression Rating Scale: 23.8+/-5.1) were studied on three consecutive nights in the sleep laboratory. In a random order, blood pressure was measured with a portable device over 24 h on either day 2 or 3. Polysomnographic data were analysed according to the criteria of Rechtschaffen and Kales. RESULTS: Compared to the control night, there was a significant increase of awakenings during the ABPM night. However, total sleeping time as well as sleep efficiency remained unchanged. Percentage of nocturnal decrease in both systolic and diastolic blood pressure was unrelated to the number of arousals. CONCLUSION: In depressed patients with severe disturbances of sleep architecture, ABPM did not lead to a prolongation of time awake or decrease in sleep efficiency.
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Lederbogen et al. (2003) conducted an RCT in Major depressive episode (n=12). Ambulatory blood pressure measurement (ABPM) vs. Control night without ABPM was evaluated on Sleep parameters (awakenings, total sleeping time, and sleep efficiency). 24-hour ambulatory blood pressure measurement significantly increased nocturnal awakenings compared to the control night, without altering total sleep time or sleep efficiency in depressed patients.
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