Key result
Accessory pathway ablation improves LV function and reduces remodeling in WPW-associated dilated cardiomyopathy.
Why the study?
Asynchronous septal motion caused by pre-excitation through a right-sided accessory pathway may deteriorate cardiac performance in dilated cardiomyopathy refractory to medical therapy.
Case Report (n=1)
No
Answers are grounded in this paper and cite their sources.
May support AP ablation in select WPW-DCM cases; leaves open generalizability and need for prospective trials.
A 55-year-old man was admitted to our hospital for further examination of the abnormalities of chest X-ray and electrocardiogram. He was diagnosed with type B Wolff-Parkinson-White syndrome concomitant with dilated cardiomyopathy. Despite the medical therapy using enalapril and carvedilol for 20 months, his cardiac performance and brain natriuretic peptide (BNP) were not so improved. Because asynchronous septal motion caused by pre-excitation through a right-sided accessory pathway (AP) might deteriorate his cardiac performance, catheter ablation to the AP was performed. Successful procedure after 17 months improved left ventricular (LV) contraction, reduced LV volume, and decreased mitral regurgitation and BNP.
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Iwasaku et al. (2008) conducted a case report in Type B Wolff-Parkinson-White syndrome concomitant with dilated cardiomyopathy (n=1). Catheter ablation of right-sided accessory atrioventricular pathway was evaluated on Left ventricular contraction, left ventricular volume, mitral regurgitation, and brain natriuretic peptide (BNP). Catheter ablation of a right-sided accessory pathway in a 55-year-old man with WPW syndrome and dilated cardiomyopathy improved LV contraction and reduced LV volume, MR, and BNP at 17 months.
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