Key result
Angiotensin II infusion produces significant antidiuresis in the river lamprey.
Why the study?
Although the renin-angiotensin hormonal system is recognized in jawless fishes, the role of homologous angiotensin II in Lampetra fluviatilis kidney function had not been examined.
No clinical implications for humans; leaves open evolutionary conservation of angiotensin II effects in vertebrates.
Intravenous infusion of angiotensin II ([Asn¹ Val⁵]-Ang II) at 10⁻⁹ mol min⁻¹ kg⁻¹ body mass produced a significant antidiuresis in river lamprey Lampetra fluviatilis, captured during upstream migration and maintained in fresh water. Although the renin-angiotensin hormonal system (RAS) is now recognized in jawless fishes, until this study, the role of homologous Ang II in L. fluviatilis kidney function had not been examined. This study provides the first evidence for an antidiuretic action of Ang II in cyclostomes and, in evolutionary terms, suggests a renal function for the RAS in early vertebrates.
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Cobb et al. (2010) studied Renal function / antidiuresis in river lamprey (Lampetra fluviatilis). Intravenous infusion of angiotensin II ([Asn¹ Val⁵]-Ang II) was evaluated on Antidiuresis (kidney function). Intravenous infusion of angiotensin II at 10⁻⁹ mol min⁻¹ kg⁻¹ body mass produced a significant antidiuresis in the river lamprey Lampetra fluviatilis.
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