Key result
High baseline red cell distribution width (≥13.55%) was independently associated with an increased risk of MACEs (HR 2.15, 95% CI 1.10-4.17, P=0.02) compared to low RDW (≤12.80%) in ACS patients.
Why the study?
Few studies had examined whether red cell distribution width (RDW) is related to glucose metabolism indices, such as fasting blood glucose (FBG) and HbA1c, diabetes mellitus state, or long-term outcomes in patients with ACS.
Cohort (n=448)
No
Demonstrates that elevated red cell distribution width predicts major adverse cardiovascular events in acute coronary syndrome with high fasting glucose, indicating coupled metabolic risk.
Introduction: Red cell distribution width (RDW) reflects the heterogeneity of red blood cell size. However, few studies examined whether RDW is related to glucose metabolism indices, such as fasting blood glucose (FBG) and hemoglobin A1c (HbA1c), diabetic mellitus (DM) state or long-term outcomes of acute coronary syndrome (ACS) patients. Methods and Results: A total of 448 consecutive patients with ACS were enrolled in this study. All patients were followed up for major cardiovascular adverse events (MACEs), and the mean follow-up was 952 days. Linear regression analysis showed that RDW inversely correlated with FBG but not HbA1c or DM. Kaplan-Meier survival curve analysis demonstrated that higher RDW levels were significantly positively associated with MACEs in the whole study population and the ACS patients with high FBG but not the low FBG group. Cox multivariate regression analysis revealed the independent function of RDW on MACEs in all ACS patients and ACS patients with high FBG. The receiver operating characteristic (ROC) curve demonstrated the optimal cutoff value of RDW for MACEs. Conclusion: We first reported that higher RDW was associated with decreased FBG but not HbA1c or DM and an increased risk of MACEs in patients with ACS. This relationship was also found in ACS patients with higher FBG levels but not in ACS patients with lower FBG.
No takes yet. Share an insight, caveat, or question.
Xiong et al. (2023) conducted a cohort in Acute coronary syndrome after percutaneous coronary intervention (n=448). High Red Cell Distribution Width (RDW ≥13.55%) vs. Low Red Cell Distribution Width (RDW ≤12.80%) was evaluated on Major adverse cardiovascular events (MACEs: composite of all-cause death, cardiac death, revascularization procedure, stroke, ACS, and heart failure) (HR 2.15, 95% CI 1.10-4.17, p=0.02). High baseline red cell distribution width (≥13.55%) was independently associated with an increased risk of MACEs (HR 2.15, 95% CI 1.10-4.17, P=0.02) compared to low RDW (≤12.80%) in ACS patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: