Why the study?
Real-world evidence shows persistent gaps in AF guideline implementation, motivating an evaluation of measurable quality-of-care indicators after Cyprus contextualised the NICE NG196 AF guideline within its national health system.
Does the introduction of contextualised NICE NG196 AF guidelines and quality-of-care indicators improve anticoagulation, screening, safety monitoring, and stroke risk stratification in patients with atrial fibrillation in Cyprus?
Does the introduction of contextualised NICE NG196 AF guidelines and quality-of-care indicators improve anticoagulation, screening, safety monitoring, and stroke risk stratification in patients with atrial fibrillation in Cyprus?
National implementation of AF guidelines in Cyprus significantly improved pulse rhythm screening in high-risk individuals, but demonstrated persistent or worsening gaps in anticoagulation safety monitoring and formal CHA₂DS₂-VASc stroke risk stratification.
Issue Atrial fibrillation (AF) is a major contributor to morbidity and mortality in the elderly, and its effective management can reduce the associated health burden. However, real-world evidence shows persistent gaps in relevant guidelines’ implementation in Europe and elsewhere. In 2023, Cyprus contextualised the NICE NG196 AF guideline within its national health system and introduced measurable quality-of-care indicators. Description of the problem We evaluated guideline implementation through four indicators using national electronic health records across three periods: baseline (2022–2023) and two post-implementation years (2023–2025). Indicators captured key management domains: anticoagulation, screening, patient safety monitoring, and stroke risk stratification. Results The proportion of AF patients admitted for stroke on anticoagulation increased from 61.1% at baseline to 69.3% in year one (+8.2%, p = 0.086), with no further improvement in year two. More interestingly, pulse rhythm assessment in high-risk individuals improved markedly from 17.1% to 39.4% (+22.3%, p < 0.001) and further to 51.4% in year two (+12%, p < 0.001). In contrast, safety monitoring in anticoagulated patients was suboptimal at baseline and year one (67.8%) and declined to 58.6% in year two (−9.2%, p < 0.001), while stroke risk stratification using the CHA₂DS₂-VASc score was very limited, at 1.2% after implementation. Lessons Improvements were observed in anticoagulation and screening, but critical gaps remain in safety monitoring and risk stratification. Our findings highlight the need for stronger, system-level implementation, including decision support tools, incentives and integration of key practices into routine workflows. Key messages • Atrial Fibrillation guideline implementation in Cyprus improved screening and anticoagulation but revealed major gaps in patient safety monitoring and risk stratification. • System-level and indicator-based monitoring can strengthen quality of care and reduce cardiovascular burden.
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Kouis et al. (2026) studied this question.
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