Key result
LAD ligation induces acute LV dysfunction and elevates cardiac biomarkers in sheep.
Why the study?
The prognostic significance of clinicopathological measurements in diagnosing experimental acute myocardial infarction in an ovine model required evaluation.
No immediate clinical implications; leaves open further validation of sheep LAD ligation as a translational MI model.
Summary To evaluate the prognostic significance of clinicopathological measurement in the diagnosis of acute myocardial infarction (MI) in sheep, acute MI was induced by ligation of left anterior descending coronary artery (LAD). For this purpose, twenty four healthy sheep were divided into the sham-operated or control group (group I, thoracotomy without MI) and the experimental group (group II, with MI) (n=12 in each), then all animals were subjected to the echocardiographic and clinicopathological analysis 2 days post-MI. Echocardiography revealed significant differences in left ventricular end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), LV ejection fraction (LVEF) and LV fractional shortening (LVFS) between groups (P<0.05). In biochemical analysis, the mean values of troponin (Trop), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) increased in the MI group compared with the control group (P<0.05). In conclusion, alterations in echocardiographic and early clinopathological mean values were observed in an ovine model of the experimental acute MI, which could aid researchers in interpreting their results when using this model for MI studies.
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Fathi et al. (2013) studied Experimental acute myocardial infarction in an ovine model (n=24). Ligation of the left anterior descending coronary artery (LAD) to induce acute MI vs. Sham-operated control (thoracotomy without MI) was evaluated on Echocardiographic (LVEDD, LVESD, LVEF, LVFS) and biochemical (troponin, AST, LDH) parameters at 2 days post-MI (p=<0.05).
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