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Dentin hypersensitivity is a common clinical condition characterized by acute, transient pain resulting from exposed dentin in response to thermal, tactile, evaporative, osmotic, or chemical stimuli, negatively affecting patients' quality of life. Given the wide availability of desensitizing toothpastes, it is essential to evaluate the scientific evidence regarding their effectiveness. The aim of this study was to analyze, through a literature review, the scientific evidence on occluding toothpastes for the treatment of dentin hypersensitivity. Scientific articles published in indexed databases were selected, focusing on the main mechanisms of action and the clinical efficacy of different desensitizing agents. The studies demonstrated that active ingredients such as fluorides, arginine, nano-hydroxyapatite, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), and bioactive glasses significantly reduce dentin hypersensitivity, primarily through dentinal tubule occlusion and, in some technologies, by inducing biomineralization processes. However, methodological heterogeneity among the studies limits direct comparisons and prevents the identification of a universally superior agent. It can be concluded that the currently available scientific evidence supports the use of occluding toothpastes as a conservative, effective, and clinically relevant therapeutic strategy for the management of dentin hypersensitivity, highlighting the importance of individualized treatment selection and evidence-based decision-making.
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Velez et al. (2026) studied this question.
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