Key result
Five clinical risk markers identify impaired glucose tolerance found in ~39% of tested patients.
Why the study?
The oral glucose tolerance test is the gold standard for diagnosing impaired glucose tolerance in hypertensive patients but is complicated to perform, making a simpler alternative based on routine clinical and laboratory parameters desirable.
Cross-Sectional (n=260)
May support targeted OGTT in select hypertensives; hypothesis-generating and requires prospective validation before practice change.
Many patients with hypertension suffer from impaired glucose tolerance or type 2 diabetes mellitus. Although these diagnoses are generally simple and reliable, it is more difficult to diagnose impaired glucose tolerance. As the gold standard (oral glucose tolerance test (OGTT)) is complicated to perform, a simpler alternative would be useful. The aims of the Pre-Diabetes Score study are to correlate demographic and/or laboratory parameters that are clinically simple to determine with the results of the OGTT and to determine the diagnostic significance of the combinations of parameters with regard to impaired glucose tolerance. A total of 260 patients were included in the evaluation; 39% had impaired glucose tolerance and 12% had diabetes mellitus. A combination of HbA1c of > or =6%, a venous fasting glucose of > or =110 mg/dl, an age of > or =55 years, a systolic blood pressure of > or =140 mmHg and an enlarged waist size is highly predictive of impaired glucose tolerance.
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Lüders et al. (2005) conducted a cross-sectional in Hypertension with suspected impaired glucose tolerance or type 2 diabetes mellitus (n=260). Pre-Diabetes Score (HbA1c ≥6%, fasting glucose ≥110 mg/dl, age ≥55 years, SBP ≥140 mmHg, enlarged waist size) vs. Oral glucose tolerance test (OGTT) was evaluated on Diagnosis of impaired glucose tolerance on oral glucose tolerance test (OGTT). Combining HbA1c ≥6%, fasting glucose ≥110 mg/dl, age ≥55y, SBP ≥140 mmHg, and enlarged waist is highly predictive of impaired glucose tolerance (present in 39% of 260 patients).
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