Key result
Frontal QRS-T angle showed no significant correlation with coronary artery disease complexity as measured by the SYNTAX-I score (rho = -0.011, p = 0.418; OR 1.0, p = 0.946).
Why the study?
This study aimed to determine the association between the frontal QRS-T angle and coronary artery disease complexity defined by the SYNTAX I score in patients presenting with chest pain excluding ACS.
Does the frontal QRS-T angle predict the anatomic complexity of coronary artery disease (SYNTAX-I score) in adults presenting with non-ACS chest pain?
Cross-Sectional (n=387)
No
Does the frontal QRS-T angle predict the anatomic complexity of coronary artery disease (SYNTAX-I score) in adults presenting with non-ACS chest pain?
In a predominantly young, male Pakistani cohort presenting with non-ACS chest pain, the frontal QRS-T angle on surface ECG showed no significant correlation with coronary artery disease complexity as measured by the SYNTAX-I score.
Answers are grounded in this paper and cite their sources.
Frontal QRS-T angle should not guide CAD complexity assessment; leaves open whether other ECG markers predict SYNTAX scores in non-ACS patients.
The study aimed to determine the association between the frontal QRS-T angle and the complexity of coronary artery disease, as defined by SYNTAX I score in patients presenting with chest pain to a tertiary cardiac care hospital, excluding those with acute coronary syndrome (ACS). The study employed has a descriptive cross-sectional design. The study was carried out at the Armed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD), Rawalpindi, Pakistan, from October 2022 to August 2024. A total of 387 patients were included in the study in accordance with the inclusion and exclusion criteria. Non-probability consecutive sampling technique was used. Frontal QRS-T angle (fQRST) is automatically calculated by ECG machines based on a standard 12-lead Electrocardiogram (ECG). SYNTAX I score was calculated to assess the anatomic complexity of the coronary vasculature through angiography. According to results, out of 387 patients, 135 had coronary artery disease, and 45 with critical disease. fQRST ranged from 0-180° (median: 15°). SYNTAX-I score ranged from 0-33 (median: 0). Spearman’s correlation analysis showed no statistically significant correlation between the fQRST, and SYNTAX-I score (rho = -0.011, p = 0.418). The study results conclude and suggest that fQRST may not be a good predictor of the complexity of coronary artery disease in our patients.
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Prof. Muhammad Shabbir (2025) conducted a cross-sectional in Stable coronary artery disease / chest pain (n=387). Frontal QRS-T angle (fQRST) vs. Normal frontal QRS-T angle / absence of CAD (SYNTAX-I score 0) was evaluated on Complexity of coronary artery disease assessed by SYNTAX-I score (OR 1.0 (Spearman's rho = -0.011), p=0.418). Frontal QRS-T angle showed no significant correlation with coronary artery disease complexity as measured by the SYNTAX-I score (rho = -0.011, p = 0.418; OR 1.0, p = 0.946).
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