Cardiac Renin-Angiotensin Signaling and Susceptibility to Extracellular Matrix Remodeling in Male Mouse Offspring Conceived by In Vitro Fertilization

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Healthy status (immune cytokine response) (n=87). Intervention: Neonatal age group (newborns) vs. Adults. Primary outcome: Balanced high secretion of stimulated IL-10 and IFN-gamma (>1,000 pg/ml).

Q: What does this research mean for the field?

Neonates exhibit an immature cytokine response compared with adults, characterized by significantly lower IL-10 secretion and heterogeneous individual orientations toward Th1, Th2, or balanced profiles. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Wangtao Jiang; Juan Wang; Lun Wei; Le Bo; Xuanping Lu; Panjie Ma; Yi Lu; 茅彩萍

doi:10.3791/74959

October 27, 2026Journal of Visualized Experiments

Cardiac Renin-Angiotensin Signaling and Susceptibility to Extracellular Matrix Remodeling in Male Mouse Offspring Conceived by In Vitro Fertilization

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Study Design

Type

Cross-Sectional (n=87)

Structured PICO

P

Population

87 healthy participants comprising 52 newborns and 35 adults assessed for peripheral blood mononuclear cell cytokine secretion.

E

Exposure

In vitro stimulation of peripheral blood mononuclear cells with lipopolysaccharide (LPS) and concanavalin-A

C

Comparator

Unstimulated baseline and comparison between 52 healthy newborns and 35 adults

O

Outcome

Patterns of interferon gamma (IFN-gamma) and interleukin-10 (IL-10) secretion by peripheral blood mononuclear cells (using a threshold level of 1,000 pg/ml to classify secretion patterns)surrogate

Main Result

Absolute Event Rate: 25% vs 77%

Implication

Neonates generally exhibit an immature IL-10 and IFN-gamma cytokine response compared with adults, with only 25% of neonates showing balanced high secretion of both cytokines compared to 77% of adults.

Abstract

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Discussion

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Cite This Study

Jiang et al. (2026) conducted a cross-sectional in Healthy status (immune cytokine response) (n=87). Neonatal age group (newborns) vs. Adults was evaluated on Balanced high secretion of stimulated IL-10 and IFN-gamma (>1,000 pg/ml).

Cardiac Renin-Angiotensin Signaling and Susceptibility to Extracellular Matrix Remodeling in Male Mouse Offspring Conceived by In Vitro Fertilization

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

Cardiac Renin-Angiotensin Signaling and Susceptibility to Extracellular Matrix Remodeling in Male Mouse Offspring Conceived by In Vitro Fertilization

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

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