Key result
Metabolic syndrome linked to ~17-point higher rate of multiple coronary lesions in young male MI.
Why the study?
Estimates of the prognostic significance of metabolic syndrome in patients with myocardial infarction are contradictory, motivating an evaluation of coronary artery features in males under 60 years old with metabolic syndrome and myocardial infarction.
Does the presence of metabolic syndrome affect coronary artery lesion characteristics in males under 60 years old with myocardial infarction?
Observational (n=166)
Does the presence of metabolic syndrome affect coronary artery lesion characteristics in males under 60 years old with myocardial infarction?
In males under 60 years old presenting with myocardial infarction, concomitant metabolic syndrome is associated with significantly more frequent multiple, extensive, and recurrent coronary artery lesions on angiography.
Metabolic syndrome was associated with more extensive coronary lesions and recurrent MI in men under 60; leaves open whether targeted strategies improve prognosis.
Relevance. Estimates of the significance of metabolic syndrome for the prognosis of a patient with a myocardial infarction are contradictory. Aim. To evaluate features of the coronary arteries state in males under 60 years old with metabolic syndrome and myocardial infarction to improve prevention and outcomes. Material and methods. The study included males aged 39-60 years old with myocardial infarction were studied. The patients were divided into two age comparable groups: I - study group, with metabolic syndrome - 32 patients; II - control, without it - 134 patients. A comparative analysis of the coronary angiography indicators was performed. Results. The study group did not differ from the control group in the frequency of complete coronary artery occlusions, the magnitude of maximum stenosis of the infarct-associated artery, the completeness of revascularization, localization and depth of myocardial damage. The study group was characterized by multiple (three or more) (in the study group: 78.1%; in the control group: 61.5%; p = 0.04) and extensive (62.5% and 28.5%, respectively; p = 0.003) coronary artery lesions, recurrent lesions (9.7% and 4.2%; p = 0.02). Conclusions. Males under than 60 years old with with metabolic syndrome and myocardial infarction are characterized by multiple, extensive lesions of the coronary arteries and a recurrent course of the disease. According to these parameters, such patients have a worse prognosis compared to the general group.
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V.V. et al. (2025) conducted an observational in Myocardial infarction and metabolic syndrome (n=166). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Multiple (three or more) coronary artery lesions (p=0.04). Metabolic syndrome in males <60 with MI was associated with higher rates of multiple (78.1% vs 61.5%, p=0.04) and extensive (62.5% vs 28.5%, p=0.003) coronary lesions.
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