Quality of Life Features Changes in Male's Under 60 Years Old With Metabolic Syndrome in the Acute and Subacute Myocardial in-Farction Periods

Relevance. Changes in the quality of life associated with heart failure in young and middle-aged males with metabolic syndrome and myocardial infarction (MI) are not well understood. Aim. To evaluate changes in the quality of life (QL) indicator associated with heart failure (HF) in males under 60 years old (y.o.) with metabolic syndrome and MI to improve prevention and out-comes. Material and methods. The study included males aged 19-60 y.o. with type I MI. Patients are divided into two age-comparable groups: I - the study group, with metabolic syndrome - 113 patients; II - control, without it - 575 patients. A comparative analysis of the QL indicator associated with HF (HFQL) (V. Ironosov) was performed in the selected groups in the first 48 hours and at the end of the third week of MI. The changes and correlations (C. Spearmen) of HFQL with clinical features, meta-bolic parameters, central and peripheral hemodynamics were studied. Results. HFQL in patients with study group (68.09 ± 18.95%) was worse than in the control group (59.71 ± 20.77%; р˂0.0001) in the first hours of MI and at the end of the third week of the disease (25.18 ± 17.74% и 19.45 ± 14.63%, respectively; p = 0.0009). A positive (58.0% and 68.6%) dynamics of HFQL were obtained from the first hours to the end of the subacute MI period in both patient groups (р˂0.0001). In the study group, significant correlations of HFQL with the activity of creatine kinase MB-fraction and the number of leukocytes in the blood, size of the left of left ventricle, its systolic and diastolic function, peripheral hemodynamic, and lipid metabolism parameters were revealed. In the control group, more correlations were found, but their strength was less. Conclusions. The quality of life associated with heart failure is worse in patients with metabolic syndrome during the acute and sub-acute MI periods. Activity of creatine kinase MB-fraction, the number of leukocytes, dilatation of the left ventricle, its systolic and diastolic dysfunction were the most associated with quality of life in the study group. The assessment of HF-related quality of life is useful as an adjunct to the examination of patients with MI, starting from the first hours of the disease, for early identification of risk groups for adverse events and chronic heart failure formation.